When an alien race and factions within Starfleet attempt to take over a planet that has "regenerative" properties, it falls upon Captain Picard and the crew of the Enterprise to defend the planet's people as well as the very ideals upon which the Federation itself was founded.

The Borg, a relentless race of cyborgs, are on a direct course for Earth. Violating orders to stay away from the battle, Captain Picard and the crew of the newly-commissioned USS Enterprise E pursue the Borg back in time to prevent the invaders from changing Federation history and assimilating the galaxy.