An embarrassing video of Anthony surfaces online right before his fifth high school reunion. The Smosh dudes then race to pull down the clip before it blows Anthony's chances of reconnecting with his teen crush Anna.

Fraternity brothers head to Las Vegas for spring break. One of them steals the sword of Thutmose III from a hotel. But they have unleashed an ancient curse, and a sand storm that slowly moves down the strip, destroying famed hotels. Seeing the massive destruction, they find out about the legend of the sword and try to stop the storm. They must find a sacred urn, the largest piece of pure gold, and the Dark Messenger. They race against time to find the items before Vegas is wiped off the map.