A mysterious virus turns humans who touch cats into felines, causing a "Nyandemic" worldwide catastrophe where people transform into cats.

Anne, an imaginative 11-year-old orphan, is mistakenly sent to live with the Cuthberts, elderly siblings who wanted a boy to help on their fields. Despite the initial misunderstanding, Anne's charm and spirit eventually win them over.

A salary worker comes to another world and takes it easy with a slow life running a drugstore.