Kara, devastated by the loss of Krypton, struggles to adjust to her new life on Earth. Superman mentors her. Meanwhile, she must contend with a mysterious group called the Dark Circle who searches for a powerful weapon held in the Academy's vault.

Ghost-Spider is on the run after being framed for her friend Kevin's murder, while Ms. Marvel, Squirrel Girl, Quake, and Patriot attempt to bring her in.