After defeating Darnell and his crime syndicate, Valerie is tasked with investigating a new drug cartel in town who's drugs are laced with fentanyl.

A team of animal rights activists unknowingly releases a genetically engineered ape from a top secret research facility, who soon grows to enormous size and embarks on a rampage of total destruction in Hollywood.

All hell breaks loose in LA when a woman returns home with her missing Father, "Patient Zero" from an infection outbreak 40 years ago.