After an earthquake rocks Washington, D.C., the Army Corps races against the clock to rescue the president, who is trapped under the rubble, while a sinister plot aims to capitalize on the disaster.

A crack-pot scientist aligns with the Axis of Evil to bring down the United States with EMP blasts, toxic zombification gas and by unleashing the ultimate undead killing monstrosity: the Z-REX. When a hot-wired militia squad and a crew of college hipsters are thrown together to do something about it, chaotic Predator-Thunder action runs amok.