Two Harkonnen sisters combat forces that threaten the future of humankind and establish the fabled sect that will become known as the Bene Gesserit.

Lyra is an orphan who lives in a parallel universe in which science, theology and magic are entwined. Lyra's search for a kidnapped friend uncovers a sinister plot involving stolen children, and turns into a quest to understand a mysterious phenomenon called Dust. She is later joined on her journey by Will, a boy who possesses a knife that can cut windows between worlds. As Lyra learns the truth about her parents and her prophesied destiny, the two young people are caught up in a war against celestial powers that ranges across many worlds.